Delta 9 THC is arguably the most widely known cannabinoid. When people refer to “getting high” they are referring to the experience of the psychoactive effects of THC. THC begins as THCA, tetrahydrocannabinolic acid, which is one of the most abundant cannabinoids found in cannabis. When THCA is heated and turned into THC, it binds to CB1 receptors in the brain producing psychoactive effects. THC is the only known cannabinoid to produce a psychoactive response, a high, and possibly, a therapeutic benefit.
CBDA, cannabidolic acid, is very abundant in the cannabis plant and turns into CBD when heated. Preclinical studies demonstrate that CBDA is a strong antiemetic. An antiemetic is used to treat vomiting and nausea and is often used to mitigate the side effects of opioid use or chemotherapy.
CBD has exploded in popularity in recent years. CBD has been the subject of much scientific interest after it hit the mainstream in 2014, following a CNN documentary in which a non-psychoactive, CBD rich cannabis strain, helped a five-year-old girl with severe epilepsy drastically reduce her daily seizure count. The FDA recently approved the first ever CBD-based drug for seizures. CBD is making waves in its ability to treat pain, nausea, anxiety, sleep disorders, and more.
This is a big one.
Cannabigerolic acid is a precursor to one of the three main cannabinoid lines: THCA, CBDA, and CBCA. CBGA is the chemical parent to THC and CBD. Do you follow?
Enzymes direct it down one of these lines before heat can change it into different forms. CBGA can help reduce inflammation and relieves pain. Inflammation is a defense mechanism; the body’s response to damage or irritants. It’s important because inflammation is the body actively trying to heal itself from a perceived danger, like a bacterial infection, injury, or food allergy.
Cannabigerolic is considered a minor cannabinoid because it is present in very low levels. It’s also powerful in treating glaucoma because it is a strong vasodilator meaning that it widens blood vessels. This helps increase blood flow and provide oxygen to the tissues that need it. CBG is showing promise as an effective antibacterial, anticancer, and neuroprotectant.
Cannabichromenic acid is one of the three main cannabinoid lines. It is used to treat fungal infections. Fungal infections like athlete’s foot, ringworm, and jock itch are commonly found on the skin.
CBC, cannabichromenic, binds poorly to CB1 receptors in the brain, but it binds well with other pain-related receptors, helping to increase the body’s levels of natural endocannabinoids. CBC may be impactful against cancer because of this. CBC has also been shown to be an inhibitor of acne. In conjunction with the THC and CBD, CBD also appears to have antidepressant effects.
THCA over time breaks down and turns into cannabinol (CBN). CBN has been shown to delay symptom onset of Lou Gehrig’s disease in mice indicating that it may help with motor neural diseases. CBN is also known for its anti-asthmatic, anti-inflammatory, and sedative properties.
Short for tetrahydrocannabivarin, THVC is similar to THC, but with a few less carbon atoms. THCV has been shown to be an anticonvulsant and has neuroprotective properties. THCV also may be an appetite suppressant, making it an agent for weight loss.
Cannabidivarin is a less potent version of CBD. The CBDV molecule is similar to CBD but has been changed in some ways. CBDV is an anti-nausea and anti-epileptic. CBDV is a powerful anticonvulsant. A 2012 study shows that CBDV stopped seizures in mice and rats.